PENGARUH PAPARAN PERASAN WORTEL TERHADAP KADAR ASAM URAT PADA LANSIA
Abstract
Uric acid is the final product of purine nucleic acids. Uric acid is filtered by the glomerulus and secreted through the distal tubule to the urine, most uric acid is reabsorbed in the proximal tubule and utilized. Uric acid is not soluble in plasma and at high concentrations will be stored in joints and tissues, it causing painful inflammation. One that can reduce hyperuricemia is carrots. Urination through food, one of the carrots can accelerate uric acid through urine. Carrots contain high antioxidants such as carotenoids such as β-carotene. Carrots have diuretic properties, N balance agents, and are effective for removing gout. Vitamin A in carrots is proven to reduce uric acid levels because vitamin A in carrots will be converted to retinoic acid and xanthin by xanthine oxidase there will be no uric acid formation. This study aims to determine the impact of carrot extract on uric acid levels in the elderly in the working area of Cimahi City Cipageran Health Center which was intervened for 30 days. The method used were quasi experimental pre post one design group. Data collection was done by measuring the uric acid level of the elderly, then intervening in giving carrot water to the elderly with gout in the working area of Cipageran Health Center and measuring uric acid levels after intervention. Analysis of univariate data with mean and bivariate tests with t test. The average result of uric acid before being given carrot extract was 7.6 mg / dL with a standard deviation of 0.417 mg / dL and an error standard of 0.07 mg / dL, while the average uric acid level after being given carrot juice was 6.7 mg / dL with a standard deviation of 0.967 mg / dL and a standard error of 0.182 mg / dL. The statistical test results obtained pValue = 0.001. From the results of the study it can be concluded that uric acid levels can be lowered due to the intervention of carrot extract.
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References
2. BPPK. Hasil Riset Kesehatan Dasar (RISKESDAS 2013). Published online 2013.
3. Smith E, Hoy D, Cross M, et al. The global burden of gout: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. Published online March 1, 2014:annrheumdis-2013-204647. doi:10.1136/annrheumdis-2013-204647
4. Bishop ML, Fody EP, Schoeff LE, eds. Clinical Chemistry: Techniques, Principles, Correlations. 6th ed. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2010.
5. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8-14. doi:10.1016/j.ijcard.2015.08.109
6. Wallace KL, Riedel AA, Joseph-Ridge N, Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J Rheumatol. 2004;31(8):1582-1587.
7. Roddy E. Revisiting the pathogenesis of podagra: why does gout target the foot? J Foot Ankle Res. 2011;4:13. doi:10.1186/1757-1146-4-13
8. Chuang S-Y, Lee S-C, Hsieh Y-T, Pan W-H. Trends in hyperuricemia and gout prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008. Asia Pac J Clin Nutr. 2011;20(2):301-308.
9. Widyanto FW. Artitis Gout dan Perkembangannya. Saintika Med. 2017;10(2):145-152.
10. Chen LX, Schumacher HR. Gout: an evidence-based review. J Clin Rheumatol Pract Rep Rheum Musculoskelet Dis. 2008;14(5 Suppl):S55-62. doi:10.1097/RHU.0b013e3181896921
11. Richette P, Bardin T. Gout. The Lancet. 2010;375(9711):318-328. doi:10.1016/S0140-6736(09)60883-7
12. Merriman TR, Dalbeth N. The genetic basis of hyperuricaemia and gout. Joint Bone Spine. 2011;78(1):35-40. doi:10.1016/j.jbspin.2010.02.027
13. Schlesinger N. Diagnosing and Treating Gout: A Review to Aid Primary Care Physicians. Postgrad Med. 2010;122(2):157-161. doi:10.3810/pgm.2010.03.2133
14. Winzenberg T, Buchbinder R. Cochrane Musculoskeletal Group review: acute gout. Steroids or NSAIDs? Let this overview from the Cochrane Group help you decide what’s best for your patient. J Fam Pract. 2009;58(7):E1-4.
15. Laubscher T, Dumont Z, Regier L, Jensen B. Taking the stress out of managing gout. Can Fam Physician. 2009;55(12):1209-1212.
16. Moghadam-Kia S, Werth VP. Prevention and treatment of systemic glucocorticoid side effects. Int J Dermatol. 2010;49(3):239-248. doi:10.1111/j.1365-4632.2009.04322.x
17. Hak AE, Choi HK. Lifestyle and gout. Curr Opin Rheumatol. 2008;20(2):179-186. doi:10.1097/BOR.0b013e3282f524a2
18. Nursidika P, Rafiqua N. Water Hyacinth (Eichhornia crassipes) Ethanolic Extract Antithromobotic Activity. 3rd Int Semin Glob Health. 2019;1(1):8-8.
19. Kanbara A, Hakoda M, Seyama I. Urine alkalization facilitates uric acid excretion. Nutr J. 2010;9:45. doi:10.1186/1475-2891-9-45
20. Sharma KD, Karki S, Thakur NS, Attri S. Chemical composition, functional properties and processing of carrot—a review. J Food Sci Technol. 2012;49(1):22-32. doi:10.1007/s13197-011-0310-7
21. Desideri G, Castaldo G, Lombardi A, et al. Is it time to revise the normal range of serum uric acid levels? Eur Rev Med Pharmacol Sci. 2014;18(9):1295-1306.
22. Amelia R, Harahap J, Wahyuni AS, Pratama A. Health status of elderly based on daily activities living, cholesterol and uric acid profile in Medan city. IOP Conf Ser Earth Environ Sci. 2018;125(1):012175. doi:10.1088/1755-1315/125/1/012175
23. Eleftheriadis T, Golphinopoulos S, Pissas G, Stefanidis I. Asymptomatic hyperuricemia and chronic kidney disease: Narrative review of a treatment controversial. J Adv Res. 2017;8(5):555-560. doi:10.1016/j.jare.2017.05.001
24. Alsultanee IR, Ewadh MJ, Mohammed MF. Novel natural anti gout medication extract from Momdica Charantia. J Nat Sci Res. 2014;4(17):16-23.
25. Kang D-H, Chen W. Uric acid and chronic kidney disease: new understanding of an old problem. Semin Nephrol. 2011;31(5):447-452. doi:10.1016/j.semnephrol.2011.08.009
26. Johnson RJ, Nakagawa T, Sanchez-Lozada LG, et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes. 2013;62(10):3307-3315. doi:10.2337/db12-1814
27. Cedars Sinai Medical Center. Magnesium Rich Food. Published online 2018. https://www.cedars-sinai.edu/Patients/Programs-and-Services/Documents/CP0403MagnesiumRichFoods.pdf
28. Hafez RM, Abdel-Rahman TM, Naguib RM. Uric acid in plants and microorganisms: Biological applications and genetics - A review. J Adv Res. 2017;8(5):475-486. doi:10.1016/j.jare.2017.05.003
29. Kaneko K, Aoyagi Y, Fukuuchi T, Inazawa K, Yamaoka N. Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperuricemia. Biol Pharm Bull. 2014;37(5):709-721. doi:10.1248/bpb.b13-00967
30. Fabbrini E, Serafini M, Baric IC, Hazen SL, Klein S. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes. 2014;63(3):976. doi:10.2337/db13-1396
31. Greene B, Stewart B. The Vegan Athlete: Maximizing Your Health & Fitness While Maintaining a Compassionate Lifestyle. Ulysses Press; 2013.
32. Lin F, Zhang H, Huang F, Chen H, Lin C, Zhu P. Influence of changes in serum uric acid levels on renal function in elderly patients with hypertension: a retrospective cohort study with 3.5-year follow-up. BMC Geriatr. 2016;16. doi:10.1186/s12877-016-0209-2
33. Mazzali M, Hughes J, Kim YG, et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-indepensdent mechanism. Hypertens Dallas Tex 1979. 2001;38(5):1101-1106.
34. Kodama S, Saito K, Yachi Y, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 2009;32(9):1737-1742. doi:10.2337/dc09-0288
35. Type 2 Diabetes: New Insights for the Healthcare Professional: 2011 Edition. ScholarlyEditions; 2012.
36. Johnson RJ, Kang D-H, Feig D, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertens Dallas Tex 1979. 2003;41(6):1183-1190. doi:10.1161/01.HYP.0000069700.62727.C5
37. Nursidika P, Mahargyani W, Anggraeni FK. Comparison Analysis of Total Cholesterol Level Examination Between Photometry and 3 Parameters Point of Care Testing Device. Med Lab Technol J. 2018;4(2):49-57. doi:10.31964/mltj.v4i2.184
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