KARAKTERISTIK DAN TATALAKSANA SINDROM EPILEPSI: SEBUAH TINJAUAN LITERATUR
Abstrak
Definisi dan klasifikasi sindrom epilepsi pertama kali disampaikan oleh International League Against Epilepsy (ILAE) tahun 1985. Menurut ILAE sindrom epilepsi merupakan gangguan epilepsi yang ditandai dengan sekelompok tanda dan gejala, yang dapat terjadi bersamaan. Gejala bergantung pada usia dan serangkaian penyakit penyerta tertentu. Penulis bertujuan menggabungkan berbagai literatur terkini mengenai sindrom epilepsi. Literatur diambil menggunakan database Google Scholar, PubMed, Cochrane Library dalam kurun waktu 4 (empat) tahun, 2019-2023. Studi yang diikutsertakan ke dalam literatur yang sesuai dengan kriteria inklusi meliputi studi yang menjelaskan mengenai sindrom epilepsi dan karakteristiknya. Klasifikasi sindrom epilepsi dibagi berdasarkan jenis kejang dan onset usia. Setiap jenis memiliki karakteristik dan tatalaksana yang berbeda. Sindrom epilepsi pada masa anak yang paling sering dijumpai meliputi, Generalized Tonic-Clonic Seizures Alone/ GTCSA, Childhood Absence Epilepsy/ CAE, Lennox-Gastaut Syndrome/ LGS, West syndrome/ WS, Self-Limited Childhood Epilepsy with Centrotemporal Spikes/ SLCECTS. Dapat disimpulkan bahwa inisiasi pengobatan antikejang pada sindrom epilepsi bergantung pada usia dan efektivitas yang berbeda dari obat antiepilepsi.
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Referensi
2. Yang Q, Hu D, Wang T, et al. Childhood epilepsy syndromes classification based on fused features of electroencephalogram and electrocardiogram. Cogn Comput Syst. 2022;4(1):1-10. doi:10.1049/ccs2.12035
3. Stödberg T, Tomson T, Barbaro M, et al. Epilepsy syndromes, etiologies, and the use of next-generation sequencing in epilepsy presenting in the first 2 years of life: A population-based study. Epilepsia. 2020;61(11):2486-2499. doi:10.1111/epi.16701
4. Howell KB, Freeman JL, Mackay MT, et al. The severe epilepsy syndromes of infancy: A population-based study. Epilepsia. 2021;62(2):358-370. doi:10.1111/epi.16810
5. Mohamed IN, Elseed MA, Mohamed S, et al. Classification and management of epilepsy and epileptic syndromes in a cohort of 202 school children- a 2 year follow up study- Sudan. BMC Neurol. 2019;19(1):1-6. doi:10.1186/s12883-019-1514-0
6. Kapoor D, Sharma S, Garg D, et al. Intravenous Methylprednisolone Versus Oral Prednisolone for West Syndrome: A Randomized Open-Label Trial. Indian J Pediatr. 2021;88(8):778-784. doi:10.1007/s12098-020-03630-3
7. Sagar P, Wawryk O, Vogrin S, et al. Efficacy and tolerability of adjuvant perampanel: an Australian multicenter real-world observational study in refractory focal and generalized epilepsy syndromes. Epilepsy Behav. 2021;119:107935. doi:10.1016/j.yebeh.2021.107935
8. Poudel P, Kafle SP, Pokharel R. Clinical profile and treatment outcome of epilepsy syndromes in children: A hospital-based study in Eastern Nepal. Epilepsia Open. 2021;6(1):206-215. doi:10.1002/epi4.12470
9. Zhao B, Liao S, Zhong X, et al. Effectiveness and Safety of Oxcarbazepine vs. Levetiracetam as Monotherapy for Infantile Focal Epilepsy: A Longitudinal Cohort Study. Front Neurol. 2022;13(June):1-9. doi:10.3389/fneur.2022.909191
10. Verma A, Kumar A. Classification Of Epilepsies And Epileptic Syndromes Using International League Against Epilepsy 2010: A Hospital Based Study From Rural Population Of North India. Int J Sci Res. 2019;90(1):60-62.
11. Wirrell E, Tinuper P, Perucca E, Moshé SL. Introduction to the epilepsy syndrome papers. Epilepsia. 2022;63(6):1330-1332. doi:10.1111/epi.17262
12. Specchio N, Pietrafusa N. New-onset refractory status epilepticus and febrile infection-related epilepsy syndrome. Dev Med Child Neurol. 2020;62(8):897-905. doi:10.1111/dmcn.14553
13. Clarkson BDS, LaFrance-Corey RG, Kahoud RJ, Farias-Moeller R, Payne ET, Howe CL. Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome. Ann Neurol. 2019;85(4):526-537. doi:10.1002/ana.25439
14. Payne ET, Koh S, Wirrell EC. Extinguishing Febrile Infection-Related Epilepsy Syndrome: Pipe Dream or Reality? Semin Neurol. 2020;40(2):263-272. doi:10.1055/s-0040-1708503
15. Serino D, Santarone ME, Caputo D, Fusco L. Febrile infection-related epilepsy syndrome (FIRES): Prevalence, impact and management strategies. Neuropsychiatr Dis Treat. 2019;15:1897-1903. doi:10.2147/NDT.S177803
16. Katyayan A, Diaz-Medina G. Epilepsy: Epileptic Syndromes and Treatment. Neurol Clin. 2021;39(3):779-795. doi:10.1016/j.ncl.2021.04.002
17. Riney K, Bogacz A, Somerville E, et al. International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022;63(6):1443-1474. doi:10.1111/epi.17240
18. Peng P, Peng J, Yin F, et al. Ketogenic diet as a treatment for super-refractory status epilepticus in febrile infection-related epilepsy syndrome. Front Neurol. 2019;10(APR). doi:10.3389/fneur.2019.00423
19. Koh S, Wirrell E, Vezzani A, et al. Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. Epilepsia Open. 2021;6(1):62-72. doi:10.1002/epi4.12447
20. Mironov, M., Chebanenko, N., Burd, S., Rubleva, Y. V., Tikhonova, O., Krasilshchikova, T., Zykov, V., & Shamalov N. The effectiveness of antiepileptic therapy in patients with epileptic syndromes associated with myoclonic seizures. Zhurnal Nevrol i Psikhiatrii Im SS Korsakova. 2020;120(4):51-59.
21. Cervenka, M. C., Wood, S., Bagary, M., Balabanov, A., Bercovici, E., Brown, M.-G., Devinsky, O., Di Lorenzo, C., Doherty, C. P., & Felton E. International recommendations for the management of adults treated with ketogenic diet therapies. Neurol Clin Pract. 2021;11(5):385-397.
22. Obara, K., & Ono T. Ketogenic diet for a young adult patient with chronic-phase febrile infection-related epilepsy syndrome. Cureus. 14(2).
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