EFEKTIVITAS PATCH TRANSDERMAL EKSTRAK SARANG BURUNG WALET (AERODRAMUS FUCIPHAGUS) TERHADAP PENYEMBUHAN LUKA PERINEUM PADA IBU POSTPARTUM
Abstract
Perineal wounds due to childbirth can cause discomfort and infection. Transdermal patches of swallow's nest extract contain glycoproteins to stimulate wound healing. The study aimed to analyze the effectiveness of transdermal patches of swallow's nest extract on the healing of perineal wounds in postpartum mothers. The method used true experiment, pre-test, and post-test with control group design with randomized simple sampling technique. The sample was 34 postpartum mothers on the first day with grade II perineal wounds and suturing, normal delivery, aged 20-35 years, normal nutritional status, no diabetes, no infection, and hemoglobin levels of 11-15g/dl, and exclusion criteria were having complications during labor and postpartum. The sample consisted of 17 people in the intervention group who were given a 2.8g transdermal patch of swallow's nest extract by attaching it to the perineum and 17 people in the control group who were given 2.8 g of swallow's nest extract gel applied topically. Both groups were given intervention twice a day for 7 days and measurements were taken 4 times, on days 1, 3, 5, and 7. The measuring instrument used the REEDA. Analysis used Friedman, Mann Whitney, and Wilcoxon tests. The transdermal patch of bird's nest extract was faster in the wound healing process than the control group with an average REEDA score of 0.29 meaning good wound healing, while in the control group, it was 3.06 meaning poor wound healing with p-value<0.05. The transdermal patch of bird's nest extract is effective for healing perineal wounds in postpartum mothers.
Full text article
Generated from XML file
References
1] A. Sulisnani, L. Dian A, A. S. Utami, N. N. Fatonah, V. Septiani, and N. Ice, “Efektifitas Senam Kegel terhadap Proses Penyembuhan Luka Perineum Ibu Post Partum,” Univ. Ngudi Waluyo, vol. 1, no. 2, pp. 1029–1038, 2022.
[2] R. Itha Idhayanti, A. Warastuti, and B. Yuniyanti, “Mobilisasi Dini Menurunkan Nyeri Akibat Jahitan Perineum Tingkat Ii Pada Ibu Post Partum,” J. Jendela Inov. Drh., vol. 3, no. 2, pp. 29–43, 2020, doi: 10.56354/jendelainovasi.v3i2.85.
[3] A. Rizky, Rafieqah Nalar and Mahardika, “Efektifitas Rebusan Daun Sirih Merah Terhadap Penyembuhan Luka Perineum Pada Ibu Postpartum Di Puskesmas Karangpawitan Kabupaten Garut,” SENTRI J. Ris. Ilm., vol. 2, no. 4, pp. 1275--1289, 2023, doi: 10.55681/sentri.v2i10.1649.
[4] Indrayani, Asuhan Persalinan dan Bayi Baru Lahir. Jakarta: Trans Info Media, 2013.
[5] S. Patria et al., Ilmu Kebidanan Sarwono, 4th ed. Jakarta: P.T. Bina Pustaka Sarwono Prawirohardjo, 2018.
[6] S. Astiti G, Runjati, Sudirman, Fatmasari D, “Efektivitas Gel Ekstrak Sarang Burung Walet (Aerodramus Fuciphagus) Terhadap Penyembuhan Luka Perineum Ibu Postpartum. Poltekkes Kemenkes Semarang; 2022. - Penelusuran Google,” 2022.
[7] C. Thorne, R. Beasley, S. J. Aston, S. P. Bartlett, and G. C. Gurtner, Grabb And Smith’s Plastic Surgery. USA: Lippincott Williams & Wilkins, 2006.
[8] M. Kuhlmann, W. Wigger-alberti, Y. Mackensen, M. Ebbinghaus, and R. Williams, “Wound healing characteristics of a novel wound healing ointment in an abrasive wound model : A randomised , intra-individual clinical investigation,” Wound Med., vol. 24, no. 1, pp. 24–32, 2019, doi: 10.1016/j.wndm.2019.02.002.
[9] Y. T. Octavia and F. L. Saragih, “Edukasi Perawatan luka perineum dengan kesembuhan luka perineum pada ibu nifas hari ke 7 di RSU Sari mutiara medan,” J. Abdimas Mutiara, vol. 1, no. 2, pp. 160–170, 2020.
[10] R. Rantika and A. Susanti, “He Effect of Sitz Bath Therapy on Intensity of Perinealwound Pain in Postpartum Mother At Pmb Dince Safrina of Pekanbaru …,” J. Ibu dan Anak, vol. 8, no. 2, pp. 15–20, 2020, doi: https://doi.org/10.36929/jia.v8i2.278.
[11] M. B. Alvarenga, A. A. Francisco, S. M. J. V. de Oliveira, F. M. B. da Silva, G. T. Shimoda, and L. P. Damiani, “Episiotomy Healing Assessment: Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) Scale Reliability,” Rev. Lat. Am. Enfermagem, vol. 23, no. 1, 2015, doi: https://doi.org/10.1590%2F0104-1169.3633.2538.
[12] P. Parni, M. Syarah, and S. M. Lisca, “Efektivitas Pemberian Rebusan Daun Sirih dan Jus Nanas terhadap Luka Perineum pada Ibu Post Partum Di Puskesmas Jagakarsa,” Innov. J. Soc. Sci. Res., vol. 4, no. 2, 2024, doi: https://doi.org/10.31004/innovative.v4i2.10032.
[13] A. D. Syalfina, D. Irawati, S. Priyanti, and A. Churotin, “Studi Kasus Ibu Nifas dengan Infeksi Luka Perineum,” J. Kesehat. Mercusuar, vol. 4, no. 1, 2022, doi: https://doi.org/10.36984/jkm.v4i1.176.
[14] Kementerian Kesehatan RI. Sekretariat Jenderal, “Profil kesehatan indonesia tahun 2020,” Kemenkes RI, vol. 48, no. 1, pp. 6–11, 2021, doi: 10.1524/itit.2006.48.1.6.
[15] C. White, “Perineal Tears.,” Lancet, vol. 218, no. 5643, p. 933, 1931, doi: 10.1016/S0140-6736(01)08912-7.
[16] Dinas Kesehatan Provinsi Sulawesi Tengah, “Profil Kesehatan Provinsi Sulawesi Tengah,” Palu, 2021.
[17] RSUD Undata Palu, “Laporan Persalinan Tahun 2022,” Palu, 2022.
[18] F. Fatimah and P. Lestari, Pijat Perineum Mengurangi Ruptur Perineum untuk Kalangan Umum, Ibu Hamil,dan Mahasiswa Kesehatan. Yogyakarta: Pustaka Baru Press, 2019.
[19] N. Arma, N. A. Sipayung, M. Syari, and N. Ramini, “Pantang Makanan terhadap Lamanya Penyembuhan Luka Perineum pada Ibu Nifas,” J. Ilmu Kesehat., vol. 4, no. 2, pp. 95–100, 2020, doi: http://dx.doi.org/10.33757/jik.v4i2.292.
[20] L. D. Sartika, N. A. Kusumastuti, R. Sartika, A. D. Susanto, and C. J. Idu, “Efektifitas Perawatan Luka dengan Povidone Iodine dan Nacl 0,9% terhadap Proses Penyembuhan Luka Catheter Double Lumen pada Pasien Hemodialisa,” Journals Ners Community, vol. 13, no. 2, pp. 293–305, 2023, doi: https://doi.org/10.55129/jnerscommunity.v13i2.2638.
[21] F. Setiawan et al., “Penyuluhan penggunaan antibiotik yang tepat dan benar dalam upaya pencegahan resistensi antibiotik,” J. Masy. Mandiri, vol. 7, no. 4, pp. 3681–3689, 2023, doi: 10.31764/jmm.v7j4.16201.
[22] N. R. N. M. S. Harahap, “Penyembuhan Luka Perineum dengan Putih Telur Ayam,” Gentle birth, vol. 4, no. 1, pp. 1–25, 2021.
[23] F. Sindi, K. Wijayanti, E. Aryati, E. Ningtyas, M. T. Kebidanan, and K. Semarang, “Pengaruh Spray Gel Ekstrak Batang Bajakah Tampala (Spatholobus Littoralis Hassk) Terhadap Penyembuhan Luka Perineum Pada Ibu Nifas,” Media Penelit. dan Pengemb. Kesehat., vol. 34, no. 3, pp. 571–584, 2024.
[24] R. Anggeriani and R. Lamdayani, “Efektifitas Pemberian Air Daun Sirih (Piper Betle L) terhadap Kecepatan Penyembuhan Luka Perineum pada Ibu Post Partum,” J. Ilmu Multi Sci. Kesehat., vol. 9, no. 1, 2018, doi: https://doi.org/10.36729/bi.v9i1.121.
[25] Y. Oktafirnanda, M. Yusran, I. Fitria, M. Muzaffar, and F. Shufyani, “Effectiveness of Giving Boiled Water Young Betel Nut (Areca Catechu) and Candis Acid (Garcinia Xanthochymus) on The Healing of Perineal Wound,” J. Pharm. Sci., vol. 5, no. 2, 2022, doi: https://doi.org/10.36490/journal-jps.com.v5i2.159.
[26] Y. Yuniarti, “Efektivitas Salep Jintan Hitam (Nigella Sativa) pada Proses Penyembuhan Luka Perineum Rupture Ibu Nifas,” J. Kesehat. Manarang, vol. 4, no. 2, 2018, doi: https://doi.org/10.33490/jkm.v4i2.76.
[27] N. Sampara, S. Sikki, and R. Aspar, “Pengaruh Mengkonsumsi Ikan Gabus Terhadap Penyembuhan Luka Perineum Pada Ibu Nifas,” Pros. Semin. Nas. Kesehat. Masy. 2022, vol. 1, no. 1, pp. 138-146., 2020.
[28] Y. Yuniarti, “Efektivitas Salep Jintan Hitam (Nigella Sativa) Pada Proses Penyembuhan Luka Perineum Rupture Ibu Nifas,” J. Kesehat. Manarang, vol. 4, no. 2, p. 64, 2018, doi: 10.33490/jkm.v4i2.76.
[29] Z. Abedian, M. Navinezhad, J. Asili, and H. Esmaeili, “An investigation into the Effect of Alpha Ointment (Fundermol) on Perineal Pain relief Following Episiotomy in Nulliparous Women,” J. Midwifery Reprod. Heal., vol. 6, no. 1, pp. 1149–1156, 2018, doi: 10.22038/jmrh.2017.9975.
[30] C. S. Ramadhan, J. Jaji, and J. Natosba, “Efektivitas Air Rebusan Biji Pinang Muda dan Asam Kandis terhadap Intensitas Nyeri dan Penyembuhan Luka Perineum pada Ibu Nifas,” J. Kesehat., vol. 13, no. 3, p. 460, 2022, doi: 10.26630/jk.v13i3.3053.
[31] farzan ghazi, Manfaat sarang burung walet untuk kecantikan. Jakarta: 2021, 2021.
[32] L. Elfita, “Analisis Profil Protein dan Asam Amino Sarang Burung Walet (Collocalia fuchiphaga) Asal Painan,” J. Sains Farm. Klin., vol. 1, no. 1, p. 27, 2015, doi: 10.29208/jsfk.2014.1.1.22.
[33] N. A. McEwan, C. A. Rème, H. Gatto, and T. J. Nuttall, “Monosaccharide inhibition of adherence by Pseudomonas aeruginosa to canine corneocytes,” Vet. Dermatol., vol. 19, no. 4, pp. 221–225, 2008, doi: 10.1111/j.1365-3164.2008.00678.x.
[34] K. B. Roh et al., “Mechanisms of Edible Bird’s Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells,” Evidence-based Complement. Altern. Med., vol. 1, no. 1, 2012, doi: 10.1155/2012/797520.
[35] D. Anggraini and L. Y. Kasmawati, “Formulasi Gel Sarang Burung Walet Putih (Aerodramus fushipagus) dan Uji Penyembuhan Luka Bakar Derajat II pada Mencit,” J. Sains Farm. Klin., vol. 4, no. 1, p. 55, 2017, doi: 10.29208/jsfk.2017.4.1.172.
[36] F. H. I. Efendi and J. Na’imah, “Formulasi dan Uji Stabilitas Fisik Gel Piroxicam Berbasis Carbomer Formulation and Physical Stability Test of Carbomer-Based Piroxicam Gel,” Pharmauho J. Farm., vol. 9, no. 1, pp. 21–25, 2023, doi: 10.33772/pharmauho.V9i1.37.
[37] I. B. S. R. D. R. L. Sumaryono, WahonoShirly Kumala, Pemanfaatan Bahan Alam sebagai Obat, Kosmetik dan Pangan Fungsional. Jakarta: Fakultas Farmasi Universitas Pancasila, 2019.
[38] N. F. Azzahrah, A. W. Jamaluddin, and Y. M. Adikurniawan, “Efektivitas Patch Sederhana Dari Ekstrak Daun Kayu Jawa (Lannea Coromandelica (Houtt.) Merr.) Terhadap Penyembuhan Luka Sayat Pada Tikus (Rattus Norvegicus),” J. Ilm. As-Syifaa, vol. 11, no. 2, pp. 169–180, 2019, doi: 10.33096/jifa.v11i2.531.
[39] S. R. Bayu Putra, “Uji Aktivitas Ekstrak Etil Asetat Daun Kayu Jawa (Lannea Coromandelic (Houtt.) Merr.) Terhadap Penyembuhan Luka Bakar Pada Tikus Putih (Rattus Norvegicus,” As-Syifaa J. Farm., vol. 12, no. 2, pp. 158–163, 2020.
[40] Safaruddin, M. Arum, S. Wahyuningsih, and R. Amin, “Uji Efektivitas Patch Transdermal Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea Coromandelica (Houtt.) Merr) terhadap Luka Sayat pada Tikus Putih Jantan (Rattus Norvegicus),” J. Multidisiplin Madani, vol. 2, no. 2, 2022.
[41] N. Nitiariksa and Sukmawati, “Pengembangan Dan Evaluasi Formula Sediaan Patch Ekstrak Daun Binahong (Anredera Cordifolia (Tenore) Steenis),” J. Pharmacopolium, vol. 4, no. 1, 2021.
[42] H. H. Kim et al., “Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts,” J. Lipid Res., vol. 46, no. 8, pp. 1712–1720, 2005, doi: 10.1194/jlr.M500105-JLR200.
[43] C. T. Guo et al., “Edible bird’s nest extract inhibits influenza virus infection,” Antiviral Res., vol. 70, no. 3, pp. 140–146, 2006, doi: 10.1016/j.antiviral.2006.02.005.
[44] D. Rahmayanti and F. Nuroini, “Uji Ekstrak Akuosa Sarang Burung Walet Putih (Collocalia fuciphaga) terhadap Penyembuhan Luka Sayat Tikus Putih (Rattus norvegicus) yang Diinduksi Pseudomonas aeroginosa,” Pros. Semin. Nas. Mhs. Unimus, vol. 2, no. 1, 2019.
[45] A. Haris, “Efektivitas Krim Ekstrak Sarang Burung Walet Terhadap Penyembuhan Luka Mencit Di Kota Bima,” J. Anal. Med. Biosains, vol. 6, no. 2, p. 120, 2019, doi: 10.32807/jambs.v6i2.150.
[2] R. Itha Idhayanti, A. Warastuti, and B. Yuniyanti, “Mobilisasi Dini Menurunkan Nyeri Akibat Jahitan Perineum Tingkat Ii Pada Ibu Post Partum,” J. Jendela Inov. Drh., vol. 3, no. 2, pp. 29–43, 2020, doi: 10.56354/jendelainovasi.v3i2.85.
[3] A. Rizky, Rafieqah Nalar and Mahardika, “Efektifitas Rebusan Daun Sirih Merah Terhadap Penyembuhan Luka Perineum Pada Ibu Postpartum Di Puskesmas Karangpawitan Kabupaten Garut,” SENTRI J. Ris. Ilm., vol. 2, no. 4, pp. 1275--1289, 2023, doi: 10.55681/sentri.v2i10.1649.
[4] Indrayani, Asuhan Persalinan dan Bayi Baru Lahir. Jakarta: Trans Info Media, 2013.
[5] S. Patria et al., Ilmu Kebidanan Sarwono, 4th ed. Jakarta: P.T. Bina Pustaka Sarwono Prawirohardjo, 2018.
[6] S. Astiti G, Runjati, Sudirman, Fatmasari D, “Efektivitas Gel Ekstrak Sarang Burung Walet (Aerodramus Fuciphagus) Terhadap Penyembuhan Luka Perineum Ibu Postpartum. Poltekkes Kemenkes Semarang; 2022. - Penelusuran Google,” 2022.
[7] C. Thorne, R. Beasley, S. J. Aston, S. P. Bartlett, and G. C. Gurtner, Grabb And Smith’s Plastic Surgery. USA: Lippincott Williams & Wilkins, 2006.
[8] M. Kuhlmann, W. Wigger-alberti, Y. Mackensen, M. Ebbinghaus, and R. Williams, “Wound healing characteristics of a novel wound healing ointment in an abrasive wound model : A randomised , intra-individual clinical investigation,” Wound Med., vol. 24, no. 1, pp. 24–32, 2019, doi: 10.1016/j.wndm.2019.02.002.
[9] Y. T. Octavia and F. L. Saragih, “Edukasi Perawatan luka perineum dengan kesembuhan luka perineum pada ibu nifas hari ke 7 di RSU Sari mutiara medan,” J. Abdimas Mutiara, vol. 1, no. 2, pp. 160–170, 2020.
[10] R. Rantika and A. Susanti, “He Effect of Sitz Bath Therapy on Intensity of Perinealwound Pain in Postpartum Mother At Pmb Dince Safrina of Pekanbaru …,” J. Ibu dan Anak, vol. 8, no. 2, pp. 15–20, 2020, doi: https://doi.org/10.36929/jia.v8i2.278.
[11] M. B. Alvarenga, A. A. Francisco, S. M. J. V. de Oliveira, F. M. B. da Silva, G. T. Shimoda, and L. P. Damiani, “Episiotomy Healing Assessment: Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) Scale Reliability,” Rev. Lat. Am. Enfermagem, vol. 23, no. 1, 2015, doi: https://doi.org/10.1590%2F0104-1169.3633.2538.
[12] P. Parni, M. Syarah, and S. M. Lisca, “Efektivitas Pemberian Rebusan Daun Sirih dan Jus Nanas terhadap Luka Perineum pada Ibu Post Partum Di Puskesmas Jagakarsa,” Innov. J. Soc. Sci. Res., vol. 4, no. 2, 2024, doi: https://doi.org/10.31004/innovative.v4i2.10032.
[13] A. D. Syalfina, D. Irawati, S. Priyanti, and A. Churotin, “Studi Kasus Ibu Nifas dengan Infeksi Luka Perineum,” J. Kesehat. Mercusuar, vol. 4, no. 1, 2022, doi: https://doi.org/10.36984/jkm.v4i1.176.
[14] Kementerian Kesehatan RI. Sekretariat Jenderal, “Profil kesehatan indonesia tahun 2020,” Kemenkes RI, vol. 48, no. 1, pp. 6–11, 2021, doi: 10.1524/itit.2006.48.1.6.
[15] C. White, “Perineal Tears.,” Lancet, vol. 218, no. 5643, p. 933, 1931, doi: 10.1016/S0140-6736(01)08912-7.
[16] Dinas Kesehatan Provinsi Sulawesi Tengah, “Profil Kesehatan Provinsi Sulawesi Tengah,” Palu, 2021.
[17] RSUD Undata Palu, “Laporan Persalinan Tahun 2022,” Palu, 2022.
[18] F. Fatimah and P. Lestari, Pijat Perineum Mengurangi Ruptur Perineum untuk Kalangan Umum, Ibu Hamil,dan Mahasiswa Kesehatan. Yogyakarta: Pustaka Baru Press, 2019.
[19] N. Arma, N. A. Sipayung, M. Syari, and N. Ramini, “Pantang Makanan terhadap Lamanya Penyembuhan Luka Perineum pada Ibu Nifas,” J. Ilmu Kesehat., vol. 4, no. 2, pp. 95–100, 2020, doi: http://dx.doi.org/10.33757/jik.v4i2.292.
[20] L. D. Sartika, N. A. Kusumastuti, R. Sartika, A. D. Susanto, and C. J. Idu, “Efektifitas Perawatan Luka dengan Povidone Iodine dan Nacl 0,9% terhadap Proses Penyembuhan Luka Catheter Double Lumen pada Pasien Hemodialisa,” Journals Ners Community, vol. 13, no. 2, pp. 293–305, 2023, doi: https://doi.org/10.55129/jnerscommunity.v13i2.2638.
[21] F. Setiawan et al., “Penyuluhan penggunaan antibiotik yang tepat dan benar dalam upaya pencegahan resistensi antibiotik,” J. Masy. Mandiri, vol. 7, no. 4, pp. 3681–3689, 2023, doi: 10.31764/jmm.v7j4.16201.
[22] N. R. N. M. S. Harahap, “Penyembuhan Luka Perineum dengan Putih Telur Ayam,” Gentle birth, vol. 4, no. 1, pp. 1–25, 2021.
[23] F. Sindi, K. Wijayanti, E. Aryati, E. Ningtyas, M. T. Kebidanan, and K. Semarang, “Pengaruh Spray Gel Ekstrak Batang Bajakah Tampala (Spatholobus Littoralis Hassk) Terhadap Penyembuhan Luka Perineum Pada Ibu Nifas,” Media Penelit. dan Pengemb. Kesehat., vol. 34, no. 3, pp. 571–584, 2024.
[24] R. Anggeriani and R. Lamdayani, “Efektifitas Pemberian Air Daun Sirih (Piper Betle L) terhadap Kecepatan Penyembuhan Luka Perineum pada Ibu Post Partum,” J. Ilmu Multi Sci. Kesehat., vol. 9, no. 1, 2018, doi: https://doi.org/10.36729/bi.v9i1.121.
[25] Y. Oktafirnanda, M. Yusran, I. Fitria, M. Muzaffar, and F. Shufyani, “Effectiveness of Giving Boiled Water Young Betel Nut (Areca Catechu) and Candis Acid (Garcinia Xanthochymus) on The Healing of Perineal Wound,” J. Pharm. Sci., vol. 5, no. 2, 2022, doi: https://doi.org/10.36490/journal-jps.com.v5i2.159.
[26] Y. Yuniarti, “Efektivitas Salep Jintan Hitam (Nigella Sativa) pada Proses Penyembuhan Luka Perineum Rupture Ibu Nifas,” J. Kesehat. Manarang, vol. 4, no. 2, 2018, doi: https://doi.org/10.33490/jkm.v4i2.76.
[27] N. Sampara, S. Sikki, and R. Aspar, “Pengaruh Mengkonsumsi Ikan Gabus Terhadap Penyembuhan Luka Perineum Pada Ibu Nifas,” Pros. Semin. Nas. Kesehat. Masy. 2022, vol. 1, no. 1, pp. 138-146., 2020.
[28] Y. Yuniarti, “Efektivitas Salep Jintan Hitam (Nigella Sativa) Pada Proses Penyembuhan Luka Perineum Rupture Ibu Nifas,” J. Kesehat. Manarang, vol. 4, no. 2, p. 64, 2018, doi: 10.33490/jkm.v4i2.76.
[29] Z. Abedian, M. Navinezhad, J. Asili, and H. Esmaeili, “An investigation into the Effect of Alpha Ointment (Fundermol) on Perineal Pain relief Following Episiotomy in Nulliparous Women,” J. Midwifery Reprod. Heal., vol. 6, no. 1, pp. 1149–1156, 2018, doi: 10.22038/jmrh.2017.9975.
[30] C. S. Ramadhan, J. Jaji, and J. Natosba, “Efektivitas Air Rebusan Biji Pinang Muda dan Asam Kandis terhadap Intensitas Nyeri dan Penyembuhan Luka Perineum pada Ibu Nifas,” J. Kesehat., vol. 13, no. 3, p. 460, 2022, doi: 10.26630/jk.v13i3.3053.
[31] farzan ghazi, Manfaat sarang burung walet untuk kecantikan. Jakarta: 2021, 2021.
[32] L. Elfita, “Analisis Profil Protein dan Asam Amino Sarang Burung Walet (Collocalia fuchiphaga) Asal Painan,” J. Sains Farm. Klin., vol. 1, no. 1, p. 27, 2015, doi: 10.29208/jsfk.2014.1.1.22.
[33] N. A. McEwan, C. A. Rème, H. Gatto, and T. J. Nuttall, “Monosaccharide inhibition of adherence by Pseudomonas aeruginosa to canine corneocytes,” Vet. Dermatol., vol. 19, no. 4, pp. 221–225, 2008, doi: 10.1111/j.1365-3164.2008.00678.x.
[34] K. B. Roh et al., “Mechanisms of Edible Bird’s Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells,” Evidence-based Complement. Altern. Med., vol. 1, no. 1, 2012, doi: 10.1155/2012/797520.
[35] D. Anggraini and L. Y. Kasmawati, “Formulasi Gel Sarang Burung Walet Putih (Aerodramus fushipagus) dan Uji Penyembuhan Luka Bakar Derajat II pada Mencit,” J. Sains Farm. Klin., vol. 4, no. 1, p. 55, 2017, doi: 10.29208/jsfk.2017.4.1.172.
[36] F. H. I. Efendi and J. Na’imah, “Formulasi dan Uji Stabilitas Fisik Gel Piroxicam Berbasis Carbomer Formulation and Physical Stability Test of Carbomer-Based Piroxicam Gel,” Pharmauho J. Farm., vol. 9, no. 1, pp. 21–25, 2023, doi: 10.33772/pharmauho.V9i1.37.
[37] I. B. S. R. D. R. L. Sumaryono, WahonoShirly Kumala, Pemanfaatan Bahan Alam sebagai Obat, Kosmetik dan Pangan Fungsional. Jakarta: Fakultas Farmasi Universitas Pancasila, 2019.
[38] N. F. Azzahrah, A. W. Jamaluddin, and Y. M. Adikurniawan, “Efektivitas Patch Sederhana Dari Ekstrak Daun Kayu Jawa (Lannea Coromandelica (Houtt.) Merr.) Terhadap Penyembuhan Luka Sayat Pada Tikus (Rattus Norvegicus),” J. Ilm. As-Syifaa, vol. 11, no. 2, pp. 169–180, 2019, doi: 10.33096/jifa.v11i2.531.
[39] S. R. Bayu Putra, “Uji Aktivitas Ekstrak Etil Asetat Daun Kayu Jawa (Lannea Coromandelic (Houtt.) Merr.) Terhadap Penyembuhan Luka Bakar Pada Tikus Putih (Rattus Norvegicus,” As-Syifaa J. Farm., vol. 12, no. 2, pp. 158–163, 2020.
[40] Safaruddin, M. Arum, S. Wahyuningsih, and R. Amin, “Uji Efektivitas Patch Transdermal Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea Coromandelica (Houtt.) Merr) terhadap Luka Sayat pada Tikus Putih Jantan (Rattus Norvegicus),” J. Multidisiplin Madani, vol. 2, no. 2, 2022.
[41] N. Nitiariksa and Sukmawati, “Pengembangan Dan Evaluasi Formula Sediaan Patch Ekstrak Daun Binahong (Anredera Cordifolia (Tenore) Steenis),” J. Pharmacopolium, vol. 4, no. 1, 2021.
[42] H. H. Kim et al., “Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts,” J. Lipid Res., vol. 46, no. 8, pp. 1712–1720, 2005, doi: 10.1194/jlr.M500105-JLR200.
[43] C. T. Guo et al., “Edible bird’s nest extract inhibits influenza virus infection,” Antiviral Res., vol. 70, no. 3, pp. 140–146, 2006, doi: 10.1016/j.antiviral.2006.02.005.
[44] D. Rahmayanti and F. Nuroini, “Uji Ekstrak Akuosa Sarang Burung Walet Putih (Collocalia fuciphaga) terhadap Penyembuhan Luka Sayat Tikus Putih (Rattus norvegicus) yang Diinduksi Pseudomonas aeroginosa,” Pros. Semin. Nas. Mhs. Unimus, vol. 2, no. 1, 2019.
[45] A. Haris, “Efektivitas Krim Ekstrak Sarang Burung Walet Terhadap Penyembuhan Luka Mencit Di Kota Bima,” J. Anal. Med. Biosains, vol. 6, no. 2, p. 120, 2019, doi: 10.32807/jambs.v6i2.150.
Authors
Nurlina, N., Runjati, R., & Sunarjo, L. (2024). EFEKTIVITAS PATCH TRANSDERMAL EKSTRAK SARANG BURUNG WALET (AERODRAMUS FUCIPHAGUS) TERHADAP PENYEMBUHAN LUKA PERINEUM PADA IBU POSTPARTUM . JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, 17(1), 45-57. https://doi.org/10.34011/juriskesbdg.v17i1.2700
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.