LITERATURE REVIEW: MOLECULAR MECHANISMS OF ACUPUNCTURE IN MALE INFERTILITY TREATMENT

Rinesia Dwiputri, Darmawi Darmawi, Afdal Afdal

Abstrak

Infertility is a condition where the inability of a couple to conceive after one year or more of sexual intercourse without using contraception. In infertility, male factors play a role of around  30-50%.  Many  factors  influence infertility  in  men,  one of  which  is  abnormal male parameters. Therapy to treat male infertility can be pharmacological and non-pharmacological, one of the non-pharmacological therapies is acupuncture. The purpose of this literature review is to determine the molecular mechanism of acupuncture in the treatment of male infertility. This type of research is a literature review with systematic analysis . The data source of this research is from  through Google Scholar using keywords used in internet searches, namely infertility and acupuncture. 7 articles were obtained and then analyzed for purpose, suitability of topics, and variables used.  The inclusion criteria used were journal themes with male infertility and acupuncture and English-language journals. While the exclusion criteria are journals with no discussion of molecular mechanisms and incomplete journals.In male infertility, acupuncture can improve male sexual disfunction, abnormal semen analysis, immunological infertility, genital inflammation, varicocele and idiophatic male infertility. Mechanism acupuncture is improve  blood circulation in the testicles and epididymis, reduce semen ROS levels, reduce inflammation, modulate the immune system, and improve sperm motility and semen parameters.

Artikel teks lengkap

##article.generated_from_xml##

Referensi

1. Stephen W. Leslie, Taylor L. Soon-Sutton MAK. Male Infertility. Treasure Isl StatPearls Publ. 2024;25(2):1-2.
2. Panjaitan RF ME. Analisis Faktor Resiko Kejadian Infertilitas Pada Perawat di RSU Sembiring. BEST J Biol Educ Sains Technol. 2020;3(2):244-250.
3. World Health Organization (WHO). International Classification of Diseases. 11th Revis ICD-11 Geneva. Published online 2018.
4. Eisenberg ML, Esteves SC, Lamb DJ, Hotaling JM, Giwercman A, Hwang K et al. Male Infertility. Nat Rev Dis Prim. 2023;9(1):1039-1572.
5. Ventimiglia E, Capogrosso P, Boeri L, et al. Infertility as a proxy of general male health: Results of a cross-sectional survey. Fertil Steril. 2015;104(1):48-55. doi:10.1016/j.fertnstert.2015.04.020
6. Lotti F, Maggi M. Sexual dysfunction and male infertility. Nat Rev Urol. 2018;15(5):287-307. doi:10.1038/nrurol.2018.20
7. Feng J, He H, Wang Y, et al. The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review. Front Endocrinol (Lausanne). 2022;13(11):1-14. doi:10.3389/fendo.2022.1009537
8. • Lee JH, Choi TY, Lee MS, Lee H, Lee M, Shin B, et al. Acupuncture for acute low back pain: a systematic review. Clin J Pain. 2013;29(2):172-85.
9 Furlong T, Wahlstedt L, Speck N, Gledhill N, Wysocki M. Acupuncture modulates hypothalamic-pituitary-gonadal axis activity and improves sperm quality in rats. Reprod Biol Endocrinol. 2018;16(1):64.
10 Xu Z, Zhang L, Feng H, Li S, Wang Y, Wei X. Effects of acupuncture on gonadotropins, testosterone, and spermatogenesis in male rats. Andrology. 2021;9(5):1150-6.
11 Zhang Y, Wang X, Li Y, Liu Y, Wu J, Li J. Effect of acupuncture on sperm quality and testosterone levels in male infertility. Fertil Steril. 2019;112(4):684-92.
12 Liu J, Yang Y, Wang Y, Luo Y, Cheng S, Ding Y. Acupuncture improves sperm motility by reducing oxidative stress in infertile males. Androl. 2020;8(2):305-10.
13 Yuan Y, Jin X, Yang L, Han Z, He Y. Acupuncture reduces sperm DNA fragmentation by enhancing antioxidant enzymes. J Androl. 2020;41(2):190-5.
14 Chen Q, Zhang X, Zhang Y, Li Y, Zhang Z. Acupuncture improves blood circulation and enhances sperm development in male infertility. J Acupunct Meridian Stud. 2017;10(5):305-11.
15 Li S, Lin W, Wu X, Deng Z, Zhong L. Acupuncture reduces inflammatory cytokines in testicular tissue and improves sperm quality in rats. Fertil Steril. 2018;109(1):95-102.
16 Chen Z, Liu C, Zhang X, Zhao X, Wang X. Acupuncture's multifaceted effects on male infertility: hormonal regulation, antioxidant enhancement, and anti-inflammatory actions. J Altern Complement Med. 2020;26(10):927-34.
17 Kavoussi B, Ross BE. The neuroimmune basis of anti-inflammatory acupuncture. Integr Cancer Ther. 2007;6(3):251-257. doi:10.1177/1534735407305892
18. Nurwati I, Murti B, Budihastuti UR, et al. Electroacupuncture Effectiveness for Treating Idiopathic Male Infertility. Med Acupunct. 2022;34(6):405-409. doi:10.1089/acu.2021.0063
19. Pei J, Strehler E, Noss U, et al. Quantitative evaluation of spermatozoa ultrastructure after acupuncture treatment for idiopathic male infertility. Fertil Steril. 2005;84(1):141-147. doi:10.1016/j.fertnstert.2004.12.056
20. Huang DM, Huang GY, Lu FE, Stefan D, Andreas N, Robert G. Acupuncture for infertility: Is it an effective therapy? Chin J Integr Med. 2011;17(5):386-395. doi:10.1007/s11655-011-0611-8
21. Nareswari I, Lestari SW, Notonegoro C. Acupuncture Therapy for Severe Oligoasthenoteratozoospermia. Med Acupunct. 2021;33(4):302-305. doi:10.1089/acu.2020.1513
22. Gao J, Zuo Y, So KH, Yeung WSB, Ng EHY, Lee KF. Electroacupuncture enhances spermatogenesis in rats after scrotal heat treatment. Spermatogenesis. 2012;2(1):53-62. doi:10.4161/spmg.19282
23. Ketabchi AA, Salajegheh S. The effects of acupuncture treatment in infertile patients with clinical varicocele. Nephrourol Mon. 2018;10(6):1-5. doi:10.5812/numonthly.65451
24. Fang Y, Su Y, Xu J, et al. Varicocele-Mediated Male Infertility: From the Perspective of Testicular Immunity and Inflammation. Front Immunol. 2021;12(8):1-9. doi:10.3389/fimmu.2021.729539
25. Zhang Y, Xu H, Wu Y CX. Treatment of subclinical varicocele with acupuncture: A case report. Elsivier. 2022;18(5):604-607.
26. Breser ML, Salazar FC, Rivero VE, Motrich RD. Immunological mechanisms underlying chronic pelvic pain and prostate inflammation in chronic pelvic pain syndrome. Front Immunol. 2017;8(7):1-11. doi:10.3389/fimmu.2017.00898
27. Paulis G. Inflammatory mechanisms and oxidative stress in prostatitis: The possible role of antioxidant therapy. Res Reports Urol. 2018;10:75-87. doi:10.2147/RRU.S170400
28. Qin Z, Wu J, Tian J, Zhou J, Liu Y, Liu Z. Network Meta-Analysis of the Efficacy of Acupuncture, Alpha-blockers and Antibiotics on Chronic Prostatitis/Chronic Pelvic Pain Syndrome. Sci Rep. 2016;6(9):1-11. doi:10.1038/srep35737
29. Pan J, Jin S, Xie Q, et al. Acupuncture for Chronic Prostatitis or Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis. Pain Res Manag. 2023;2023(1):1-13.
30. Ng EHY, So WS, Gao J, Wong YY, Ho PC. The role of acupuncture in the management of subfertility. Fertil Steril. 2008;90(1):1-13. doi:10.1016/j.fertnstert.2008.02.094
31. Guthrie HD, Welch GR. Effects of reactive oxygen species on sperm function. Theriogenology. 2012;78(8):1700-1708. doi:10.1016/j.theriogenology.2012.05.002
32. Wazir J, Ullah R, Li S, et al. Efficacy of acupuncture in the treatment of chronic prostatitis-chronic pelvic pain syndrome: a review of the literature. Int Urol Nephrol. 2019;51(12):2093-2106. doi:10.1007/s11255-019-02267-2
33. Sun W, Guan Q, Wen J, et al. Calcium- and integrin-binding protein-1 is down-regulated in the sperm of patients with oligoasthenozoospermia: CIB1 expression in patients with oligoasthenozoospermia. J Assist Reprod Genet. 2014;31(5):541-547. doi:10.1007/s10815-014-0177-4

Penulis

Rinesia Dwiputri
rinesiadp@gmail.com (Kontak utama)
Darmawi Darmawi
Afdal Afdal
Dwiputri, R., Darmawi, D., & Afdal, A. . (2025). LITERATURE REVIEW: MOLECULAR MECHANISMS OF ACUPUNCTURE IN MALE INFERTILITY TREATMENT. JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103, 17(1), 338–353. https://doi.org/10.34011/juriskesbdg.v17i1.2781

Rincian Artikel