Efektivitas Gel Veragreens Ekstrak Daun Kubis (Brassica oleracea) dan Aloe vera terhadap Penyembuhan Luka dan Aktivitas Antiinflamasi In Vivo

Diani Aliansy; Annisa Susilawati; Siti Jaojah; Yusri Ika Widyawardani; Malika Nurul Silmi; Siti Mariam; Adira Adira; Halisa Dina Aulia; Rena Mariska; Ayva Fidya Nurhali; Sifanni Tri Rahmania; Santi Nurmala; Zellyatu Alma'wa

doi:10.34011/juriskesbdg.v18i1.3014

Diani Aliansy, Annisa Susilawati, Siti Jaojah, Yusri Ika Widyawardani, Malika Nurul Silmi, Siti Mariam, Adira Adira, Halisa Dina Aulia, Rena Mariska, Ayva Fidya Nurhali, Sifanni Tri Rahmania, Santi Nurmala, Zellyatu Alma'wa

https://doi.org/10.34011/juriskesbdg.v18i1.3014

Issue
Vol. 18 No. 1 (2026): Jurnal Riset Kesehatan Poltekkes Depkes Bandung

Keywords:

aloe vera, veragreens, anti-inflammantory activity, cabbage leaf extract (Brassica oleracea), in vivo wound healing aktivitas antiinflamasi, ekstrak daun kubis (Brassica olearacea), penyembuhan luka in vivo, veragreens

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Abstract

Background: A common issue faced by breastfeeding mothers is nipple cracks and breast engorgement, which can hinder the breastfeeding process and reduce the frequency of breastfeeding. Traditional remedies, such as direct breast milk application or cabbage leaf compresses, are often considered impractical.

Objective: This study aimed to evaluate the effectiveness of Veragreens, a topical gel formulated with a combination of cabbage leaf extract (15%) and aloe vera (25%), in accelerating wound healing and reducing inflammation in vivo using mice (Mus musculus).

Methods: This experimental study involved three treatment groups: a negative control, a positive control (Flamar/aloe vera gel), and a treatment group using Veragreens. Phytochemical tests showed that cabbage extract contains flavonoids with anti-inflammatory properties, while aloe vera contains mannose-6-phosphate, which supports tissue regeneration.

Results: The results demonstrated that Veragreens accelerated wound healing, as indicated by faster wound closure and hair regrowth by day 7. Anti-inflammatory testing revealed a significant reduction in inflammation volume (p < 0.001) in the Veragreens groups, although slightly slower than the positive control. No significant differences were observed in overall effectiveness between the Veragreens and positive control groups.

Conclusion: Veragreens has the potential to serve as a safe and effective topical solution for simultaneously treating nipple cracks and breast engorgement, making it a promising natural care product for breastfeeding mothers.

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