UJI AKTIVITAS EKSTRAK DAUN DAN BUAH BELIMBING WULUH (Averrhoa bilimbi) SEBAGAI ANTIDIABETES MELALUI INHIBISI α-AMILASE
Abstract
Diabetes mellitus is a group of disorders characterized by hyperglycemia. The leaves and fruit of Averrhoa bilimbi may be used to treat type 2 diabetes mellitus by inhibiting the action of the α-amylase enzyme. This research was conducted to determine the potential of Averrhoa bilimbi leaves and fruit extracts in inhibiting the action of the α amylase enzyme in vitro. The activity test of Averrhoa bilimbi leaves and fruit extract was carried out using the DNS method with 3 test groups, namely negative control (without sample or standard), positive control (acarbose), and test solution (extract of Averrhoa bilimbi leaves and fruit) with a concentration of 10 ppm , 15 ppm, 20 ppm, 25 ppm, and 30 ppm. The results obtained were expressed as IC50 values sequentially for acarbose, leaves extract, and fruit extract, namely 32,0397 ppm, 30,2749 ppm, and 16,1616 ppm. data were analyzed by Post Hoc ANOVA test, which showed a significant difference between acarbose and Averrhoa bilimbi fruit extract (p < 0.05). It is concluded that the extract of both Averrhoa bilimbi leaves and fruit has anti-diabetes potential in vitro.
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