Medication adherence, clinical outcome and quality of life in dyslipidemia patients: a cross-sectional study
Abstract
Background: Dyslipidemia is a disease that requires long - term drug therapy. High in medication adherence is necessary to achieve the good clinical outcome and quality of life.
Objective: This study aimed to provide medication adherence, clinical outcome, and quality of life in dyslipidemia patients and assess the influencing factors.
Methods: This study used a cross - sectional design conducted at Universitas Indonesia Hospital. Morisky Medication Adherance Scale-8 (MMAS-8) questionnaire and EQ-5D-5L questionnaire were used to assess patient’s medication adherence and quality of life. Statistical analysis was carried out using the Chi – Square test with confidence interval of 95%. This study involved 81 dyslipidemia patients in the period from September 15th to October 14th 2025.
Results: This study showed that 64.2% of patients had high medication adherence. A total of 88.9% of dyslipidemia patients had controlled total cholesterol levels, and 90.1% had a good quality of life. Gender, age, education, comorbidities, number of medications, and duration of therapy did not affect medication adherence, clinical outcomes, or quality of life among dyslipidemia patients. However, duration of therapy was found to be associated with the quality of life of dyslipidemia patients (p=0.049).
Conclusion: Most dyslipidemia patients had high medication adherence, controlled total cholesterol levels, and a good quality of life. Duration of therapy was associated with the quality of life of dyslipidemia patients.
Full text article
References
2. Pirillo A, Casula M, Olmastroni E, Norata GD, Catapano AL. Global Epidemiology of Dyslipidemia. Nat Rev Cardiol. 2021; 18 (10): 689-700 doi:10.1038/S41569-021-00541-4
3. Kementerian Kesehatan RI. Laporan Nasional: Riset Kesehatan Dasar (Riskesdas) Tahun 2018 ; 2018
4. Alfadda AA, Youssef AM, Al-Sofiani ME, et al. Medication Adherence and Treatment Satisfaction With Lipid-Lowering Drugs Among Patients With Diabetes and Dyslipidemia. Annals of Pharmacotherapy. Published online February 1, 2024 doi:10.1177/10600280241262513
5. Anwar VA, Hasan D, Keban SA, Saibi Y, Kharisma S, Pamulang P. Education Conducted By Pharmacist in Improving Hyperlipidemic Patient Adhearance. Indian J Public Health Res Dev. 2019; 10(7)
6. Made SAHI, Wayan TN, Putu WON, Putu DD. Hyperlipidemia is a Dominant Risk Factor For Coronary Heart Disease. Jurnal Berkala Epidemiologi. 2023; 11(1): 25-31 doi:10.20473/JBE.V11I12023.25-31
7. World Health Organization. WHOQOL - Measuring Quality of Life. Geneva, Switzerland: World Health Organization: 2012
Accessed February 27, 2025
8. Park H. The Impact of Dyslipidemia on the Health-Related Quality of Life of Korean Females Aged 50 Years and Older. Iran J Public Health. 2019;48(3):556 doi:10.18502/ijph.v48i3.903
9. Farsani AM, Dhanaraju MD. Risk Factors, Assessment, and Health Related Quality of Life in Patients with Dyslipidemia in a Tertiary Care Hospital India. Balneo and PRM Research Journal. 2025; 16(1) doi:10.12680/BALNEO.2025.770
10. Al-Efishat E, Jarab AS, Al-Qerem W, Abu-Zaytoun L. Factors Associated with Medication Non-Adherence in Patients with Dyslipidemia. Healthcare 2021, Vol 9, Page 813. 2021;9(7):813 doi:10.3390/HEALTHCARE9070813
11. Riani DA, Ikawati Z, Kristina SA. Validation of The Indonesian Version of Morisky Medication Adherance Scale-8 in Adult Hypertension Patients at Community Health Centers in Sleman and Yogyakarta. 2017. Tesis tidak dipublikasikan. Universitas Gajah Mada
12. Raffli A, Yuswar MA, Rizkifani S. Pengukuran Kualitas Hidup Penderita Hipertensi Menggunakan Instrumen EQ-5D-5L. Journal Syifa Sciences and Clinical Research. 2023;5(1) doi:10.37311/jsscr.v5i1.18103
13. Zulfa NRA, Rosady DS. Hubungan Jenis Kelamin dengan Kejadian Dislipidemia pada Rumah Sakit Umum Daerah Cibabat Kota Cimahi. SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat. 2025; 4(3): 1009-1017 doi:10.55123/sehatmas.v4i3.5917
14. Arif M, Sandro M. Hubungan Usia dan Jenis Kelamin terhadap Kadar Kolesterol. Jurnal Ilmu Kesehatan dan Gizi. 2024; 3(1): 51-61 doi:10.55606/jig.v3i1.3395
15. Li Y, Zhao L, Yu D, Ding G. The Prevalence and Risk Factors of Dyslipidemia in Different Diabetic Progression Stages among Middle-Aged and Elderly Populations in China. PLoS One. 2018; 13(10): e0205709. doi:10.1371/JOURNAL.PONE.0205709
16. Apriliany F, Ikawati Z, et al. The Influence of Comorbid and Types of Therapy on Total Cholesterol of Dyslipidemic Patients. JMPF. 2021; 11(3):153-163. doi:10.22146/jmpf.64328
17. Fadilah H, Martha Indria D, Wibisono N. Correlation of Polypharmacy with Potential Drug Interactions in Patients Prescribing Antihyperlipidemia Drugs. 2023. Tesis tidak dipublikasikan. Universitas Islam Malang
18. Anwar VA, Tanty HN, Qomariah N. The Relationship Between Family Roles in Improving Antihypertension Medication in Hypertension Patients in Penggilingan, East Jakarta. Jurnal Farmasi IKIFA. 2025: Vol.4(1)
19. Hijriyati Y, Wulandari NA, Sutandi A. Descriptive Analysis: Age and Medication Compliance in Diabetes Mellitus Patients. Binawan Student Journal. 2023; Vol.5(2)
20. Eliza D, Syafhan NF, Andrajati R, Fitriani SW. Medication Adherence, Glycemic Control and Quality of Life in Patients with Type 2 Diabetes Mellitus: a cross-sectional study. Jurnal Sains Farmasi & Klinis. 2023; 10(1):21 doi:10.25077/JSFK.10.1.21-27.2023
21. Hakim N, Aulia A, Anshari Z, Susanto B. Hubungan Tingkat Pengetahuan Masyarakat dengan Tinggi Kolesterol di Desa Sei Mencirim Tahun 2023. Global: Jurnal Ilmiah Multidisiplin. 2024; 1(3):88-93 doi:10.37985/GLOBAL.V1I3.32
22. Nurul Azrina A, Arsyad M. Correlation of Comorbidities with the Quality of Life Among
Pre-Geriatric COVID-19 Survivors in Jakarta Greater Area and Its Review in Islamic Perspective. YARSI Academic Journal. 2023; 1(6)
Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.