CORRELATION OF HbA1c LEVELS AND PLATELET INDICES (MPV, PDW, P-LCR, PCT) IN TYPE 2 DIABETES MELLITUS PATIENTS
Abstrak
Prolonged diabetes mellitus (DM) can lead to microvascular and macrovascular complications. The increased risk of complications is closely associated with uncontrolled blood glucose levels, which can be assessed using the HbA1c parameter. The elevated risk of vascular complications arises due to a prothrombotic state, partly caused by increased platelet activity. Platelet activity can be evaluated through platelet indices, namely Mean Platelet Volume (MPV), Platelet Distribution Widht (PDW), Platelet Large Cell Ratio (P-LCR) and Plateletcrit (PCT). This study aims to analyze the relationship between HbA1c levels and platelet indices (MPV, PDW, P-LCR, PCT) in Type 2 DM patients. The type of research used is an analytical survey with a correlation study approach using secondary data from 107 samples of Type 2 DM patients with inclusion criteria: type 2 DM patients with HbA1c levels ≥ 6.5% and exclusion criteria: patients have not received blood transfusions in the last 3 months, DHF and Anemia taken at Bandung Kiwari Hospital, selected using a purposive sampling technique with a sample size calculated using the Lemeshow formula. HbA1c levels were measured using the HPLC ion-exchange method. While the platelet index was calculated using an automatic hematology device. Statistical analysis was performed using the Spearman correlation test. The results showed a weak positive correlation between HbA1c levels and PCT (correlation coefficient r = 0.197 and p = 0.042), while no significant relationship was found between HbA1c levels and MPV, PDW and P-LCR with (MPV: r = -0.041, p = 0.67; PDW: r = 0.039, p = 0.69; P-LCR: r = -0.009, p = 0.93).
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Penulis
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